The pandemic has hastened a rise in remote working for knowledge-based organizations. This has notable benefits: Companies can save on real estate costs, hire and utilize talent globally, mitigate immigration issues, and experience productivity gains, while workers can enjoy geographic flexibility. At the same time, concerns include how to communicate across time zones, share knowledge that isn’t yet codified, socialize virtually and prevent professional isolation, protect client data, and avoid slacking. Research into work-from-anywhere (WFA) organizations and groups that include the United States Patent and Trademark Office, Tata Consultancy Services, and GitLab (the world’s largest all-remote company) highlights best practices and can help leaders decide whether remote work is right for their organizations.